Anti-Aging
MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c)
Last updated: March 2026
Sequence
16 amino acids
Origin
Mitochondrial-derived peptide
Available From
6 suppliers
Forms
1 types
Key Benefits
1
Mitochondrial-derived exercise mimetic2
May improve metabolic function3
Studied for insulin sensitivity4
Potential longevity applicationsHow It Works
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene. It acts as a metabolic regulator and exercise mimetic by activating AMPK pathways, improving glucose uptake, and enhancing fatty acid oxidation. Naturally released during exercise, MOTS-c levels decline with age, making it a target for anti-aging research.
Research Highlights
📄First mitochondrial-derived peptide shown to regulate nuclear gene expression
📄Activates AMPK (cellular energy sensor) pathway
📄Improves insulin sensitivity in animal models
📄Levels decline with age and increase with exercise
📄Research suggests it may improve physical performance and metabolic health
Available Forms
- Lyophilized powder for injection
Research Dosing
Research protocols typically use 5-10mg subcutaneous, 3-5 times per week. Dosing is based on animal studies and early human research.
⚠️ For research reference only. Not medical advice.
Legal Status
MOTS-c is available for research purposes. Not FDA-approved. Not a controlled substance.
Check legal status by country →Compare Prices
Full comparison →P
Peptides Lab UK
lyophilized powder · · —
75
Good$28.99
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B
BuyDeus
lyophilized powder · · —
70
Good$50.00
—
S
Sports Technology Labs
lyophilized powder · 5 mg · —
60
Fair$59.99
—
P
Platinum Lion
· · —
55
Fair$114.99
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R
Ruo Bio
· · —
55
Fair$3600.00
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I
Ion Peptide
· · —
55
Fair$3800.00
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